High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection
β Scribed by Georg M. Lauer; Eleanor Barnes; Michaela Lucas; Joerg Timm; Kei Ouchi; Arthur Y. Kim; Cheryl L. Day; Gregory K. Robbins; Deborah R. Casson; Markus Reiser; Geoffrey Dusheiko; Todd M. Allen; Raymond T. Chung; Bruce D. Walker; Paul Klenerman
- Book ID
- 119757926
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 425 KB
- Volume
- 127
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Hepatitis C virus (HCV), a hepatotropic RNA virus, is a major causative agent of chronic hepatitis, liver cirrhosis, and hepatocellular carcinomas. The host immune responses, especially cellular immune responses, play an important role in viral clearance, liver injury, and persistent HC
Several lines of evidence have suggested that immune mechanisms are involved in the pathogenesis of hepatitis B virus (HBV)-and hepatitis C virus (HCV)-related hepatitis. Study of patients with dual HBV and HCV infection raises the question of which is etiologically more relevant in determining the