✦ LIBER ✦

Characterization of the cellular immune response in hepatitis C virus infection

✍ Scribed by Xinjian Zhang; Jun Dou; Markus W. Germann

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 290 KB
Volume: 29
Category: Article
ISSN: 0198-6325
DOI: 10.1002/med.20157

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✦ Synopsis

Abstract

Hepatitis C virus (HCV), a hepatotropic RNA virus, is a major causative agent of chronic hepatitis, liver cirrhosis, and hepatocellular carcinomas. The host immune responses, especially cellular immune responses, play an important role in viral clearance, liver injury, and persistent HCV infection. A thorough characterization of the HCV cellular immune responses is important for understanding the interplays between host immune system and viral components, as well as for developing effective therapeutic and prophylactic HCV vaccines. Recent advances that provide better understanding the cell immune responses in HCV infection are summarized in this article. © 2009 Wiley Periodicals, Inc. Med Res Rev, 29, No. 6, 843–866, 2009

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