High proportion of recurrent germline mutations in theBRCA1gene in breast and ovarian cancer patients from the Prague area
✍ Scribed by Petr Pohlreich, Michal Zikan, Jana Stribrna, Zdenek Kleibl…
- Book ID
- 120700003
- Publisher
- BioMed Central
- Year
- 2005
- Tongue
- English
- Weight
- 176 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1465-5411
- DOI
- 10.1186/bcr1282
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In this study we genotyped Turkish breast/ovarian cancer patients for BRCA1/BRCA2 mutations: protein truncation test (PTT) for exon 11 BRCA1 of and, multiplex PCR and denaturing gradient gel electrophoresis (DGGE) for BRCA2, complemented by DNA sequencing. In addition, a modified restriction assay w
There is strong evidence that overtly inactivating mutations in RAD51C predispose to hereditary breast and ovarian cancer but the prevalence of such mutations, and whether they are associated with a particular clinical phenotype, remains unclear. Resolving these questions has important implications