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High proportion of novel mutations ofBRCA1andBRCA2in breast/ovarian cancer patients from Castilla-León (central Spain)

✍ Scribed by Mar Infante; Mercedes Durán; Eva Esteban-Cardeñosa; Cristina Miner; Eladio Velasco


Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
227 KB
Volume
51
Category
Article
ISSN
1435-232X

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Mutational analysis of BRCA2 in Spanish
✍ Mercedes Duran; Eva Esteban-Cardeñosa; Eladio Velasco; Mar Infante; Cristina Min 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 32 KB 👁 2 views

Mutations in BRCA1 and BRCA2 account for approximately 5% of the overall familial risk of breast cancer. We have carried out a mutational analysis of the entire coding sequence of the BRCA2 gene in 150 breast cancer patients from Castilla-Leon by two different methods: Protein Truncation Test (PTT)