High pressure intramolecular Diels-Alder reactions of the furan diene
β Scribed by Brian A. Keay; Peter W. Dibble
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 147 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A variety of substituted furans a-6J undergo the intramolecular Die&Alder reaction at high pressure (12.5 kbar) to provide oxatricyclo adducts Q-12) within 24 hours at room temperature.
π SIMILAR VOLUMES
An internal Diels-Alder reaction, using furan as the diene component, formed a highly functionalized 5-membered carbocycllc ring in excellent yield. Solvent and substituent effects of this reaction were examined. In connection with a proJect devoted to the synthesis of some natural products contai
The Intramolecular Diels-Alder reactions of furans possessing a 2-alkyl substituent with a terminal @unsaturated ketone have been surveyed. The consequences of varying the degree of substitution of the furan, the bridging chain length, and position of the activating group on the dienophile upon the
Depending on the reaction conditions the intramolecular Diels-Alder reaction of furan-diene 14 yields predominantly either one of two adducts 16a and 16b , which possess the necessary --functionality for eventual transformation into corticosteroids. The dienophile was intro-