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High performance liquid chromatography with electrochemical detection. 1: Separation of Cannabis constituents and quantitation of Δ9 tetrahydrocannabinol

✍ Scribed by Masoud, A. N. ;Wingard, D. W.

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
352 KB
Volume
2
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

A simple, isocratic high performance liquid chromatography system (HPLC) with electrochemical detection (EC) was used to study Cannabis constituents. Several Cannabis extracts and reference standards were examined. A total of eleven constituents were separated, and three major cannabinoids; Δ^8^, Δ^9^ tetrahydrocannabinol (THC) and cannabidiol (CBD) were identified. A linear relationship was established for the quantitation of the halucinogenic constituent Δ^9^ THC. Minor contaminants in Δ^9^ THC reference standard, which were not detected by gas chromatography (GC) were detected for the first time. The detection limits of Δ^9^ THC and related cannabinoids were in the low nanogram range (2–20 ng).

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