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High-performance liquid chromatography in combination with field desorption mass spectrometry: separation and identification of building blocks for polynucleotide synthesis

✍ Scribed by H. Seliger; T.C. Bach; H.-H. Görtz; E. Happ; M. Holupirek; B. Seemann-Preising; H.-M. Schiebel; H.-R. Schulten

Book ID: 108336899
Publisher: Elsevier Science
Year: 1982
Tongue: English
Weight: 1024 KB
Volume: 253
Category: Article
ISSN: 1873-3778
DOI: 10.1016/s0021-9673(01)88361-8

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This work describes real examples of classes of drugs (drug candidates) whose quantitative determination in biological matrices by high performance liquid chromatography with electrospray tandem mass spectrometry (LC/MS/MS) may be hampered by interferences from drug-related biotransformation product