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High-performance liquid chromatographic study of the reduction of protected oxytocein by sodium in liquid ammonia

✍ Scribed by A. Péter; F. Lukács; K. Burger; I. Schón; M. Lów; L. Kisfaludy

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
412 KB
Volume
507
Category
Article
ISSN
1873-3778

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✦ Synopsis

A combined high-performance liquid chromatographic (HPLC)-electrochemical method was developed to investigate the mechanism of reduction of protected oxytocein by metallic sodium in liquid ammonia. The changes in the redox potential and conductivity of protected oxytocein solution provided information on the stoichiometry of the reduction. HPLC methods elaborated for the identification and selective determination of the reaction intermediates and products were used to analyse the compounds formed. This combined procedure revealed the reaction path of the reduction processes and permitted optimization of the experimental conditions to increase the yield of oxytocin.

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A fast and simple procedure was developed for the quantitative determination of vincristine sulfate for use in preformulation studies. The procedure involves the use of high-performance liquid chromatography with a reverse-phase column and a mobile phase containing the sodium salt of 1-pentanesulfon