𝔖 Bobbio Scriptorium
✦   LIBER   ✦

High-performance liquid chromatographic separation of stereoisomers of N-phthaloyl-protected amino acids and dipeptidomimetics

✍ Scribed by István Ilisz; Steven Ballet; Karolien Van Rompaey; Rien De Wachter; Dirk Tourwé; Daniel W. Armstrong; Antal Péter

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
748 KB
Volume
30
Category
Article
ISSN
1615-9306

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The stereoisomers of N‐phthaloyl‐protected amino acids and dipeptidomimetics were separated on macrocyclic glycopeptide and cellulose‐based chiral stationary phases (CSPs) in the RP and polar‐ionic modes. The effects of the organic modifier, the mobile phase composition, and the pH on the separations were investigated. Optimization of these separations was achieved through variation of the mobile‐phase additive combinations. The elution sequence was determined for some of the samples. A practical application for the monitoring of the reaction conditions for N‐phthaloylation of (S)‐Phe was demonstrated.

📜 SIMILAR VOLUMES

High-performance liquid chromatographic
High-performance liquid chromatographic chiral separation of β2-homoamino acids
✍ Zoltán Pataj; Robert Berkecz; István Ilisz; Aleksandra Misicka; Dagmara Tymecka; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 425 KB 👁 1 views

## Abstract Reversed‐phase high‐performance liquid chromatographic methods were developed for the separation of enantiomers of eleven unnatural β^2^‐homoamino acids on chiral stationary phases containing macrocyclic glycopeptides (teicoplanin‐containing Chirobiotic T and T2) or the macrocyclic pept

The development of high-performance liqu
The development of high-performance liquid chromatographic analysis of allyl and allyloxycarbonyl side-chain-protected phenylthiohydantoin amino acids
✍ Cynthia G. Fields; Albert Loffet; Steven A. Kates; Gregg B. Fields 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 487 KB

Ten phenylthiohydantoin (PTH) amino acids possessing allyl (Al) or allyloxycarbonyl (Aloc) side-chain-protecting groups have been characterized by high-performance liquid chromatography for use in Edman degradation sequence analysis. Optimized separation of side-chain-protected and -unprotected PTH