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High-performance liquid chromatographic method for quantitation of pentamidine in blood serum

โœ Scribed by Charlotte M. Dickinson; Thomas R. Navin; Frederick C. Churchill


Publisher
Elsevier Science
Year
1985
Weight
562 KB
Volume
345
Category
Article
ISSN
0378-4347

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High performance liquid chromatographic
โœ Besenfelder, E. ;Endele, R. ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 215 KB ๐Ÿ‘ 2 views

Spironolactone (I), a potassium sparing diuretic, is widely used in the treatment of edema. Metabolic degradation starts with rapid deacetylation, leading to the short lived a-thiol [l]. Subsequent elimination of hydrogen sulfide yields canrenone (II), which exists in enzymatic equilibrium with canr