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High Performance Liquid Chromatographic (HPLC) Determination of Centchroman in Human Serum and Application to Single-Dose Pharmacokinetics

✍ Scribed by Jyoti Kumar Paliwal; Ram Chandra Gupta; Pyara Krishen Grover; Omkar P. Asthana; Jagdishwar Sahai Srivastava; Swaran NityaNand

Book ID
110343543
Publisher
Springer US
Year
1989
Tongue
English
Weight
499 KB
Volume
06
Category
Article
ISSN
0724-8741

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A high-performance liquid chromatographic method was developed to determine stobadin pharmacokinetics in dog and man. The relative bioavailability of stobadin dipalmitate compared with dihydrochloride was 46.4 per cent in dog. In man peak serum concentrations ranged from 12 to 289 ng ml-1 after a si