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High-performance liquid chromatographic enantiomer separation and determination of absolute configurations of phosphinic acid analogues of dipeptides and their α-aminophosphinic acid precursors

✍ Scribed by Michael Lämmerhofer; Dieter Hebenstreit; Elena Gavioli; Wolfgang Lindner; Artur Mucha; Paweł Kafarski; Piotr Wieczorek

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
246 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

The enantiomers of N-benzyloxycarbonyl-phosphinic pseudodipeptides and their N-benzyloxycarbonyl-a-aminophosphinic acid precursors as well as various other structural analogues were separated on a set of cinchona alkaloid-derived chiral anion-exchangers by HPLC in the reversed-phase mode. Semi-preparative scale chromatography provided single enantiomers in 100 mg quantities. The configurations of the enantiomers were assigned indirectly by enantioselective chromatography on the basis of the elution order and was confirmed by enantiomeric reference compounds.

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