High-performance liquid chromatographic analysis of (E)-5-(2-bromovinyl)-2′-deoxyuridine and its metabolites in serum, urine and herpes simplex virus type-1 infected cells
✍ Scribed by Nana K. Ayisi; Richard A. Wall; Erik De Clercq; Stephen L. Sacks
- Book ID
- 108449635
- Publisher
- Elsevier Science
- Year
- 1986
- Weight
- 510 KB
- Volume
- 375
- Category
- Article
- ISSN
- 0378-4347
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The influence of (E)-5-(2-bromovinyl)-2'-de~xyuridine (BVDU), caffeic acid oxidation product (KOP), and trisodiumphosphonoformate (TPF) on the course of the primary cutaneous herpes simplex virus infection was investigated by means of a guinea pig test model. The antiviral substances were applied in
## Abstract With development of antiviral drugs, the need to identify a virus as to drug sensitivity becomes increasingly of importance. The compound (E)‐5‐(2‐bromovinyl)‐2′‐deoxyuridine (BVDU) has been shown to be much more inhibitory to the replication of herpes simplex virus type 1 (HSV‐1) and v