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High-performance ligand-exchange chromatography of amino acids on chiral stationary phases

✍ Scribed by Carunchio, V. ;Messina, A. ;Sinibaldi, M. ;Fanali, S.

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
332 KB
Volume
11
Category
Article
ISSN
0935-6304

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✦ Synopsis

Three chiral stationary phases, obtained by grafting silica gel with (-)-trans-l,2-~ycIohexanediamine, were studied for the resolution of a-amino acids by ligand-exchange chromatography.The packings were prepared by bonding thechiral ligand to silica gel via different hydrocarbon spacers. Separation of the optical isomers was accomplished by eluents containing a constant concentration of copper(l1) acetate (0.05m~). The elution sequence of amino acids was found to be dependent on the grafting reaction selected to prepare the chiral packings.

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