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Direct chiral separation of unnatural amino acids by high-performance liquid chromatography on a ristocetin a-bonded stationary phase

✍ Scribed by Gabriella Török; Antal Pëter; Daniel W. Armstrong; Drik Tourwë; Gëza Töth; Jänos Säpi

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
439 KB
Volume
13
Category
Article
ISSN
0899-0042

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✦ Synopsis

Abstract

Direct high‐performance liquid chromatographic chiral separation of numerous underivatized unnatural amino acids on a ristocetin A‐bonded chiral stationary phase used in the reversed‐phase and in the polar organic chromatographic modes is reported. The effects of different parameters such as mobile phase composition, temperature, and the structure of the analytes on the selectivity in both chromatographic modes are discussed. By variation of the parameters, the separation of the stereoisomers was optimized and, as a result, baseline resolution was achieved in most cases. Chirality 13:648–656, 2001. © 2001 Wiley‐Liss, Inc.

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