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High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

✍ Scribed by Tanno, Toshihiko; Bhanu, Natarajan V; Oneal, Patricia A; Goh, Sung-Ho; Staker, Pamela; Lee, Y Terry; Moroney, John W; Reed, Christopher H; Luban, Naomi LC; Wang, Rui-Hong

Book ID: 109933038
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 263 KB
Volume: 13
Category: Article
ISSN: 1078-8956
DOI: 10.1038/nm1629

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## Abstract Protein expression in mammalian cells is key for the production and manufacturing of bio‐therapeutics with human‐like properties and activities. As a molecular basis for reaching high protein expression levels, efficient promoter/enhancer systems are a prerequisite. Here we identify a n