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High frequency of HIF-1α overexpression in BRCA1 related breast cancer

✍ Scribed by Petra van der Groep; Alwin Bouter; Fred H. Menko; Elsken van der Wall; Paul J. van Diest

Book ID
106377704
Publisher
Springer US
Year
2007
Tongue
English
Weight
172 KB
Volume
111
Category
Article
ISSN
0167-6806

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We identified 17 BRCA1 mutations in 86 Austrian breast and ovarian cancer families (20%) that were screened for mutations by denaturing high-performance liquid chromatography (DHPLC) and the protein truncation test (PTT). Eleven distinct mutations were detected, 4 of them (962del4, 2795del4, 3135del