High frequency of cord blood lymphocytes against mycobacterial 65-kDa heat-shock protein
β Scribed by Heinrich Peter Fischer; Claire E. M. Sharrock; Gabriel S. Panayi
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 240 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0014-2980
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## Abstract Recent evidence has pointed to the mycobacterial 65βkDa heatβshock protein (hsp 65) as an antigen that may be important in the pathogenesis of rheumatoid arthritis (RA). Using limiting dilution analysis the frequency of purified protein derivative of tuberculin (PPD) and hsp 65βresponsi
## DR3-restricted T cells from different HLA-DR3-positive individuals recognize the same peptide (amino acids 2-12) of the mycobacterial 65-kDa heat-shock protein* Studies in experimental animals have demonstrated that the T cell response to immunogenic proteins is limited to one or a few epitopes