High frequency of class 3 allele in the human insulin gene in Japanese Type 2 (non-insulin-dependent) diabetic patients with a family history of diabetes
β Scribed by M. Nomura; N. Iwama; M. Mukai; Y. Saito; R. Kawamori; M. Shichiri; T Kamada
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 335 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0012-186X
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The possibility of linkage between the human insulin receptor gene locus and diabetes was examined in three Type 2 (non-insulin-dependent) diabetic families and one family with maturity onset diabetes of the young. Insulin receptor gene haplotypes were established using BglII, Rsal and Sstl restrict
Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segments under non-denaturing conditions and variants were sequenced. A variant pattern was detec