High frequency of BRCA1/2 germline mutations in consecutive ovarian cancer patients in Poland
✍ Scribed by Izabela Brozek; Karolina Ochman; Jarosław Debniak; Lucyna Morzuch; Magdalena Ratajska; Magdalena Stepnowska; Maciej Stukan; Janusz Emerich; Janusz Limon
- Book ID
- 113961385
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 140 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0090-8258
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In this study we genotyped Turkish breast/ovarian cancer patients for BRCA1/BRCA2 mutations: protein truncation test (PTT) for exon 11 BRCA1 of and, multiplex PCR and denaturing gradient gel electrophoresis (DGGE) for BRCA2, complemented by DNA sequencing. In addition, a modified restriction assay w
Germline mutations in the BRCA2 gene have been shown to be associated with familial female and male breast cancer. Mutations occur throughout the entire coding region of the gene, and there is considerable ethnic and geographical diversity in the deleterious mutations detected in different populatio