## Abstract There is a great body of evidence linking a high fat diet with the formation of gallstones. However, the effect of fat __per se__ on obstructive liver damage (not involving gallstone formation) has not been assessed. The aim of this work was to study the effect of a high fat diet on liv
High fat diet induces ceramide and sphingomyelin formation in rat’s liver nuclei
✍ Scribed by Grzegorz Chocian; Adrian Chabowski; Małgorzata Żendzian-Piotrowska; Ewa Harasim; Bartłomiej Łukaszuk; Jan Górski
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 336 KB
- Volume
- 340
- Category
- Article
- ISSN
- 0300-8177
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Cholesterol 7a-hydroxylase (CYP7A1) is the rate-limiting enzyme in the bile acid biosynthetic pathway that converts cholesterol into bile acids in the liver. Recent studies have shown that bile acids may play an important role in maintaining lipid, glucose, and energy homeostasis. However, the role