High expression of PKA regulatory subunit 1A protein is related to proliferation of human melanoma cells
β Scribed by Mantovani, G; Bondioni, S; Lania, A G; Rodolfo, M; Peverelli, E; Polentarutti, N; Veliz Rodriguez, T; Ferrero, S; Bosari, S; Beck-Peccoz, P
- Book ID
- 110072817
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 434 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0950-9232
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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio