High-dose thiotepa and hematopoietic stem cell transplantation in pediatric malignant mesenchymal tumors: a phase II study
✍ Scribed by Lafay-Cousin, L; Hartmann, O; Plouvier, P; Méchinaud, F; Boutard, P; Oberlin, O
- Book ID
- 110012739
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 55 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0007-1188
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Background. The aim of this phase I study was to define the maximum tolerated dose (MTD) of thiotepa (TT), administered with busulfan (BU) 480 mg/m 2 and etoposide 2,400 mg/m 2 , followed by autologous bone marrow transplantation (ABMT) or peripheral blood stem cell transplantation (APBSCT) support
The field of high-dose chemotherapy with stem cell transplantation has been expanded recently as a treatment for solid tumors and hematological malignancies. Severe emesis remains one of the main extramedullary side-effects of high-dose regimens during the first week of treatment. Traditional antiem