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High-dose naloxone in tardive dyskinesia

✍ Scribed by Jean-Pierre Lindenmayer; Eliot Gardner; Elkhonon Goldberg; Lewis A. Opler; Stanley R. Kay; Herman M. van Praag; Michelle Weiner; Stephen Zukin

Book ID: 119095021
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 830 KB
Volume: 26
Category: Article
ISSN: 0165-1781
DOI: 10.1016/0165-1781(88)90083-2

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## Abstract The effects of both opiate agonists and the opiate antagonist naloxone were examined in a rodent model of tardive dyskinesia (TD). Chronic (˜20 weeks) administration of fluphenazine resulted in the emergence of vacuous chewing mouth movements (VCMs), a response which may be a useful mod