High-dose cytosine arabinoside and daunorubicin postremission therapy in adults with de novo acute myeloid leukemia
✍ Scribed by G. Heil; P. S. Mitrou; D. Hoelzer; M. Freund; H. Link; G. Ehninger; B. Steinke; S. Öhl; H. Wandt; E. Fackler-Schwalbe; G. Schlimok; A. Lösch; W. Queißer; B. Löffler; W. Gaus; J. Högel; H. Heimpel; E. Kurrle
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 746 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0939-5555
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High dose cytosine arabinoside (HD-AraC) was evaluated 1) as remission induction therapy for refractory acute leukemia and high risk AML, 2) as augmentation therapy for acute leukemia, and 3) as conditioning therapy prior to allogeneic bone marrow transplantation for acute leukemia. Seven of 10 pati
## BACKGROUND. Peripheral nerve toxicity has been reported but is not a commonly recognized complication of high dose cytosine arabinoside (HDAC) therapy. This study was undertaken to estimate the prevalence and describe the clinical spectrum of acute polyneuropathy associated with HDAC therapy fo