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High-dose cyclophosphamide in refractory myasthenia gravis with MuSK antibodies

✍ Scribed by Peter T. Lin; Beth A. Martin; Ann B. Weinacker; Yuen T. So

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 63 KB
Volume: 33
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.20411

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✦ Synopsis

Abstract

We describe a 48‐year‐old woman with seronegative myasthenia gravis (MG) and high‐titer of anti‐MuSK antibody. She had severe bulbar and respiratory weakness with minimal limb weakness for 2 years. Her disease responded poorly to all the conventional immunosuppressive regimens. Treatment with immunoablative dose of cyclophosphamide led to dramatic and sustained remission of her symptoms. High‐dose cyclophosphamide is an effective alternative in patients with unusually refractory disease. Muscle Nerve, 2005

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