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Cholinergic neuromuscular hyperactivity in patients with myasthenia gravis seropositive for MuSK antibody

✍ Scribed by Anna Rostedt Punga; Roland Flink; Håkan Askmark; Erik V. Stålberg

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 151 KB
Volume: 34
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.20515

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✦ Synopsis

Abstract

A 75‐year‐old man with severe oculobulbar myasthenia gravis (MG) treated with acetylcholine esterase inhibitors (AChEIs) was found to have muscle‐specific tyrosine kinase (MuSK) antibodies. Neurophysiological examination displayed extra repetitive discharges after the compound motor action potential (CMAP) at low‐frequency stimulation, possibly triggered by AChEI. This indicates an abnormal sensitivity to acetylcholine in patients with MuSK antibodies and may be a useful indicator of the adverse effect of AChEI treatment in these patients. Muscle Nerve, 2006

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