✦ LIBER ✦

High dose chemotherapy with autologous stem cell support in the treatment of patients with ovarian carcinoma : Long term results for 105 patients

✍ Scribed by Takao Shinozuka; Tsuyoshi Miyamoto; Toshinari Muramatsu; Takeshi Hirasawa; Masaru Murakami; Tsunehisa Makino; Yutaka Tanaka

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 132 KB
Volume: 85
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19990401)85:7<1555::aid-cncr17>3.0.co;2-4

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

In this study, the authors reviewed long term results and prognostic factors of high dose chemotherapy (HDC) with autologous stem cell support administered to 105 patients with epithelial ovarian carcinoma.

METHODS.

Prior to HDC, platinum-based chemotherapy was given to optimize (n ϭ 94) and/or to mobilize peripheral blood stem cells (n ϭ 33). After maximum debulking surgery, HDC with stem cell support was given; it consisted of cyclophosphamide, doxoribicin, and cisplatin (Regimen A, administered to 58 patients) or cyclophosphamide and carboplatin (Regimen B, administered to 47 patients).

RESULTS.

Five-year overall and disease free survival (OS, DFS) rates (%) according

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