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A phase I/II study of sequential, dose-escalated, high dose ifosfamide plus doxorubicin with peripheral blood stem cell support for the treatment of patients with advanced soft tissue sarcomas

✍ Scribed by Carsten Bokemeyer; Anke Franzke; Jörg T. Hartmann; Christoph Schöber; Lubomir Arseniev; Bernd Metzner; Hartmut Link; Lothar Kanz; Hans-J. Schmoll

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 85 KB
Volume: 80
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19971001)80:7<1221::aid-cncr4>3.0.co;2-n

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✦ Synopsis

ide combined with full dose doxorubicin chemotherapy supported with peripheral blood stem cells (PBSC) and granulocyte-colony stimulating factor (G-CSF) in

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## BACKGROUND. Paclitaxel, an effective chemotherapeutic agent in the management of breast carcinoma, may have activity in women whose disease has recurred after high dose chemotherapy. With this is mind the authors explored the addition of a 120-hour continuous infusion of paclitaxel to a previou