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High-dose chemotherapy and autologous bone marrow rescue for patients with refractory germ cell tumors. Early intervention is better tolerated

✍ Scribed by Robert J. Motzer; Subhash C. Gulati; John P. Crown; Steven Weisen; Maryanne Doherty; Harry Herr; William Fair; Joel Sheinfeld; Pramod Sogani; Paul Russo; George J. Bosl


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
682 KB
Volume
69
Category
Article
ISSN
0008-543X

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Background. Patients with relapsed germ cell cancer (GCT) have a poor prognosis when treated solely with conventional chemotherapy; high dose chemotherapy with autologous bone marrow rescue (ABMR) has shown curative potential in patients with relapsed and refractory GCT. This protocol was designed t

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## Abstract We report the case of a 8‐month‐old girl who presented with a metastatic malignant germ cell tumor (MGCT) that proved to be resistant to chemotherapy, including salvage platinum‐based combination therapy, surgery, and metastatectomy. The child was then treated with high‐dose carboplatin