Long-term disease-free survival in a child with refractory metastatic malignant germ cell tumor treated by high-dose chemotherapy with autologous bone marrow rescues
✍ Scribed by Devalck, Christine ;Tempels, Didier ;Ferster, Alina ;De Laet, Marc-Henri ;Bujan, Willem ;Heiman, Pierre ;Sariban, Eric
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 255 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
Abstract
We report the case of a 8‐month‐old girl who presented with a metastatic malignant germ cell tumor (MGCT) that proved to be resistant to chemotherapy, including salvage platinum‐based combination therapy, surgery, and metastatectomy. The child was then treated with high‐dose carboplatin, etoposide, and cyclophosphamide with autologous bone marrow rescue (ABMR) for two courses, since the first course was well tolerated and resulted in serum α‐f etoprotein normalisation. The child remains in complete remission 3 years post‐ABMR and 4 years post‐diagnosis, with no detectable treatment‐related sequelae. Thus, as already reported in adults, dose‐intensive chemotherapy with ABMR may have curative potential in children with refractory MGCT.