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High density lipoprotein inhibits the activation of sterol regulatory element-binding protein-1 in cultured cells

✍ Scribed by Masaki Yoshida; Nagakatsu Harada; Keiko Yoshida; Tadahiko Nakagawa; Takaaki Shimohata; Kazuaki Mawatari; Akira Takahashi; Hiroshi Sakaue; Yutaka Nakaya

Book ID: 113621890
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 942 KB
Volume: 584
Category: Article
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2010.02.034

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## Abstract AMP‐activated protein kinase (AMPK) is an intracellular fuel sensor that plays a key role in regulating fatty acid synthesis in liver. Sterol regulatory element‐binding protein (SREBP)‐1c is a master regulator of hepatic lipogenic gene expression. It has long been documented that AMPK a