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High degree of conservation in the hepatitis B virus core gene during the immune tolerant phase in perinatally acquired chronic hepatitis B virus infection

✍ Scribed by Hakan Bozkaya; Ulus S. Akarca; Brick Ayola; Anna S.F. Lok

Book ID
118567774
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
974 KB
Volume
26
Category
Article
ISSN
0168-8278

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## Abstract We analyzed the evolution of the precore/core gene of hepatitis B virus (HBV) over a period of 6 to 11 years in seven patients with chronic HBV infection, who exhibited a variety of clinical features. Sequence analysis revealed the following results: (1) HBeAg to anti‐HBe seroconversion