Hepatitis B virus variants with core gene deletions in the evolution of chronic hepatitis B infection
β Scribed by G Marinos; F Torre; S Gunther; MG Thomas; H Will; R Williams; NV Naoumov
- Book ID
- 119755514
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 242 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0016-5085
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## Abstract The polymerase chain reaction (PCR) and DNA sequencing were used to examine genomic variation in the preβcore/core open reading frame of the hepatitis B virus (HBV) in chronically infected patients. Gel electrophoresis of amplification products showed the presence of shortened forms of
## Abstract We analyzed the evolution of the precore/core gene of hepatitis B virus (HBV) over a period of 6 to 11 years in seven patients with chronic HBV infection, who exhibited a variety of clinical features. Sequence analysis revealed the following results: (1) HBeAg to antiβHBe seroconversion