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High cyclin E/low p27Kip1expression is associated with poor prognosis in astrocytomas

✍ Scribed by Takashi Tamiya, Shinichiro Mizumatsu, Yasuhiro Ono, Tomoyasu Abe, Kengo Matsumoto, Tomohisa Furuta, Takashi Ohmoto


Book ID
113039495
Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
113 KB
Volume
101
Category
Article
ISSN
0001-6322

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## Abstract ## BACKGROUND Two families of tumor suppressor genes, Cip/Kip (p21, p27, and 57) and INK4 (p15, p16, p18, and p19), regulate cell proliferation and neoplastic transformation. p27 exerts its suppressor effect through cyclin E‐dependent kinase (CDK2) by inhibiting the phosphorylation of

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## BACKGROUND. Low expression of p27 kip1 , a dominant cyclin-dependent kinase inhibitor involved in G1-S transition of the cell cycle, recently has been reported to be associated with aggressive tumor growth. It has been shown that active cell proliferation alludes to poor prognosis in patients w

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Background and Objectives: p27Kip1 is an inhibitor of cyclindependent kinases and is speculated to be a potential prognostic indicator in numerous human cancers. We investigated expression of p27Kip1 along with cyclin D1 in gastric cancer to estimate the clinical utility of p27Kip1. Methods: Immunoh