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High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

โœ Scribed by Ko, Sun-Young; Park, Chan-Jeoung; Park, Sang-Hyuk; Cho, Young-Uk; Jang, Seongsoo; Seo, Eul-ju; Kim, Nayoung; Kim, Dae-Young; Koh, Kyung Nam; Im, Ho Joon; Seo, Jong-Jin; Chi, Hyun-Sook

Book ID
122996981
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
855 KB
Volume
38
Category
Article
ISSN
0145-2126

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AML patients with normal karyotype comprise the largest subgroup (โˆผ50%) but have a highly heterogeneous clinical course. By multiparameter flow cytometry we analyzed CD7 expression along with other phenotypic markers in 185 patients with normal-karyotype AML. CD7 was expressed in 68 (37%) patients.