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High concentrations of naloxone attenuate N-methyl-D-aspartate receptor-mediated neurotoxicity

✍ Scribed by Janice P. Kim; Mark P. Goldberg; Dennis W. Choi


Book ID
115880758
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
269 KB
Volume
138
Category
Article
ISSN
0014-2999

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Microglia have been shown to be immunostimulated by inflammatory cytokines and produce a number of toxic mediators. Here we report that immunostimulated microglia can synergistically enhance the Nmethyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in rat cerebellar granule cells (CGC) in cult