High- and low-leukemogenic variants of the radiation leukemia virus (RadLV): Immunogenic, suppressive and genetic properties in relation to leukemogenic activity

✍ Scribed by Eitan Yefenof; Ya'acob Ben David; Moshe Kotler

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: French
• Weight: 819 KB
• Volume: 34
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910340621

✦ Synopsis

C57BL/6 (B6) mice inoculated with the highly leukemogenic variant of the radiation leukemia virus (A-RadLV) develop suppressor cells capable of abrogating potential anti-tumor immunity in vitro and in vivo. Inoculation of B6 animals with the low-leukemogenic D-RadLV variant does not result in suppressor cell generation but induces antitumor reactive lymphocytes. A-RadLV and D-RadLV are not leukemogenic in BALB/c or (B6 X BALB/c)F1(F1) mice, and reactive but not suppressor lymphocytes could be demonstrated in F1 animals inoculated with either virus. Infectivity assays and fingerprint analysis revealed that A-RadLV and D-RadLV contain viruses with N and B tropism. In addition, thymoma cells induced by A-RadLV produced another virus with a fingerprint pattern containing X-MuLV elements. The possible implications of the different virus types on the immunogenic and leukemogenic properties of the RadLV variants are discussed.