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High- and low-leukemogenic variants of the radiation leukemia virus (RadLV) differ in ability to induce tumor-specific immune suppression

✍ Scribed by Eitan Yefenof; David Zilcha

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
494 KB
Volume
30
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Adult C57BL/6 mice inoculated intrathymically (i.t.) with the highly leukemogenic variant of the radiation leukemia virus (A‐RadLV) develop suppressor cells capable of specifically abrogating a potential anti‐tumor cytotoxic response in vitro. Suppressor cells were generated directly by the virus, independently of an initiation of a leukemogenic process. Inoculation of C57BL/6 animals with the low leukemogenic D‐RadLV variant did not result in suppressor cell generation. It is proposed that induction of tumor‐specific immune suppression by A‐RadLV is essential for tumor progression, and the leukemogenic activity of D‐RadLV is attributed to its inability to recruit suppressor cells.

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High- and low-leukemogenic variants of the radiation leukemia virus (RadLV): Immunogenic, suppressive and genetic properties in relation to leukemogenic activity
✍ Eitan Yefenof; Ya'acob Ben David; Moshe Kotler 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 819 KB

C57BL/6 (B6) mice inoculated with the highly leukemogenic variant of the radiation leukemia virus (A-RadLV) develop suppressor cells capable of abrogating potential anti-tumor immunity in vitro and in vivo. Inoculation of B6 animals with the low-leukemogenic D-RadLV variant does not result in suppre