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Hierarchical differentiation of multipotent progenitor cells

✍ Scribed by Reed A. Flickinger

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
62 KB
Volume
21
Category
Article
ISSN
0265-9247

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✦ Synopsis

Selection of a pathway of differentiation in multipotent progenitor cells may depend on the amount of histone H1 or H1Β°relative to the core histones. With low levels of these linker histones, it is proposed that an evolutionarily more ancient cell differentiation occurs. Greater repetition of AT-rich regulatory motifs allows more frequent, hence earlier, transcription of genes, accounting for this type of cell differentiation. It is further proposed that a decrease of total cell protein accumulation leads to an increase of histone H1 or H1Β°relative to the core histones. It is suggested that these linker histones preferentially bind the more AT-rich regulatory sequences, thereby restricting the phylogenetically more ancient differentiation potency. This allows differentiation of an evolutionarily younger cell type.

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