## Abstract Glucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytom
Hidden receptors for nerve growth factor in PC12 cells
โ Scribed by Antonio CATTANEO; Silvia BIOCCA; Sergio NASI; Pietro CALISSANO
- Book ID
- 115121987
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 609 KB
- Volume
- 135
- Category
- Article
- ISSN
- 1432-1327
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๐ SIMILAR VOLUMES
Treatment of PC12 cells with dexamethasone leads, in a period of days, to a 60% decrease in the binding of (125I)nerve growth factor. The decrease was maximal after 3 days of treatment with 1 microM dexamethasone, but some decrease was seen after 6 hr and at concentrations as low as 10 nM. The effec
Treatment of PC12 cells with nerve growth factor (NGF) produces a rapid and transient increase in calcium uptake into the cells. The increased uptake is maximal after 5 minutes of NGF treatment, but after 15 minutes of NGF treatment, no such increase can be observed. The effect of NGF is partially i