Hibernomas are characterized by rearrangements of chromosome bands 11q13-21

✍ Scribed by Fredrik Mertens; Anders Rydholm; Otte Brosjö; Helena Willéd; Felix Mitelman; Nils Mandahl

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: French
• Weight: 379 KB
• Volume: 58
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910580408

✦ Synopsis

Cytogenetic analysis revealed structural rearrangements of I Iq 13-21 in 9 lipogenic t u m o r s 4 hibernomas, 4 typical lipomas and I mixed myxoid and well-differentiated liposarcoma.

Two hibernomas and all lipomas simultaneously showed aberrations attributable to previously recognized cytogenetic subgroups among benign adipose tissue tumors, i.e., supernumerary ring chromosomes or rearrangements of 6p, 12q 13-15, or I3q. The sole anomaly in the liposarcoma was a 4-way translocation t(9; I I ;22; I2)(q2 I ;q I3;q I I ;q 13). an aberration that has not previously been detected in either myxoid or well-differentiated liposarcomas. Together with our 4 cases, a total of 7 cytogenetically aberrant hibernomas have been reported. Five tumors have shown rearrangements of I I q I3 and 2 of I I q2 I, indicating that this segment of chromosome I I harbors one or more genes of importance in hibernoma development. Rearrangements of I lq13-21 also appear to be frequent in typical lipomas; a total of 8 typical lipomas with I I q 13-2 I changes have been described, including those in our series. In all but I, however, breakpoints were also found in 6p, 12q 13-I 5, or I3q.