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Hexose metabolism in pancreatic islets: Effect of D-glucose upon D-fructose metabolism

✍ Scribed by O. Scruel; A. Sener; W.J. Malaisse

Book ID
110242934
Publisher
Springer
Year
1999
Tongue
English
Weight
52 KB
Volume
197
Category
Article
ISSN
0300-8177

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Glucose-6-phosphatase activity was measured in rat liver or pancreatic islet crude homogenates and microsomes. The data recorded in the liver were comparable to those reported in prior studies. However, in the islets, the hydrolysis of D-glucose 6-phosphate by disrupted microsomes represented, when

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In pancreatic islets prepared from fed rats and incubated at a low concentration (1 . 7 mM) of D-glucose, D-mannoheptulose (10 . 0 mM) virtually fails to aect the metabolism of the hexose. Likewise, in islets from starved rats, the relative extent of the inhibitory action of D-mannoheptulose upon D-