𝔖 Bobbio Scriptorium
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Hexose metabolism in pancreatic islets: The glucose-6-phosphatase riddle

✍ Scribed by Miguel-Angel Perales; Abdullah Sener; Willy J. Malaisse

Publisher
Springer
Year
1991
Tongue
English
Weight
410 KB
Volume
101
Category
Article
ISSN
0300-8177

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✦ Synopsis

Glucose-6-phosphatase activity was measured in rat liver or pancreatic islet crude homogenates and microsomes. The data recorded in the liver were comparable to those reported in prior studies. However, in the islets, the hydrolysis of D-glucose 6-phosphate by disrupted microsomes represented, when expressed relative to the protein content, less than 2% of the value recorded in liver microsomes. Moreover, no phosphotransferase activity was detected in the islets. These findings impose reservation on both the presence of glucose-6-phosphatase in rat islets and its participation to stimulus-secretion coupling.

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