## Abstract The effect of a single i.p. dose of 200 or 300 mg kg^−1^ hexachloro‐1:3‐butadiene (HCBD) on liver morphology, water, sodium and potassium ion content, cation movement and non‐protein sulphydryl (NP‐SH) content has been studied in rats. There was a rapid, dose‐related increase in liver w
Hexachloro-1:3-butadiene-induced renal tubular necrosis in the mouse
✍ Scribed by J. Ishmael; Iona Pratt; E. A. Lock
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 958 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0022-3417
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Renal, biliary, pulmonary and faecal excretion experiments were carried out with labelled hexachloro-1,3butadiene ([I4C]HCBD) in male Sprague-Dawley rats, given orally (p.0.) and intravenously (i.v.) in doses of 1 and 100 mg kg-' as a solution in polyethylene glycol. The radioactivity excreted over
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