Renal, biliary, pulmonary and faecal excretion experiments were carried out with labelled hexachloro-1,3butadiene ([I4C]HCBD) in male Sprague-Dawley rats, given orally (p.0.) and intravenously (i.v.) in doses of 1 and 100 mg kg-' as a solution in polyethylene glycol. The radioactivity excreted over
Renal and hepatic glutathione concentrations in rats after treatment with hexachloro-1,3-butadiene and citrinin
β Scribed by Jack Mc C. Baggett; William O. Berndt
- Publisher
- Springer-Verlag
- Year
- 1984
- Tongue
- English
- Weight
- 402 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0340-5761
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π SIMILAR VOLUMES
Male Sprague Dawley rats with cannulated bile duct (BDC rats) received 100 or 200 mg kg-I labelled hexachloro-l,3-butadiene ([I4C]HCBD) by gavage 1 h (BDCI rats) or 24 h (BDCM rats) after surgical cannula implantation. Twenty-four hours after treatment with HCBD, rats were examined histochemically a
## ABSTRACT Hexachloroβ1:3βbutadiene (HCBD) causes kidney injury specific to the __pars recta__ of the proximal tubule. In the present studies, injury to the nephron was characterized at 24βh following a single dose of HCBD, using a range of quantitative urinary measurements, renal histopathology a