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Hexabromocyclododecane facilitates FSH activation of ERK1/2 and AKT through epidermal growth factor receptor in rat granulosa cells

✍ Scribed by Fa, Svetlana; Samardzija, Dragana; Odzic, Ljubica; Pogrmic-Majkic, Kristina; Kaisarevic, Sonja; Kovacevic, Radmila; Andric, Nebojsa

Book ID: 121562287
Publisher: Springer-Verlag
Year: 2013
Tongue: English
Weight: 776 KB
Volume: 88
Category: Article
ISSN: 0340-5761
DOI: 10.1007/s00204-013-1133-2

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## Abstract Previous studies demonstrated that hydrogen peroxide (H~2~O~2~) is a tumor promoter in the rat liver epithelial cell line T51B. We investigated the pathway linking H~2~O~2~ to tumor promotion. H~2~O~2~ can directly induce tyrosine phosphorylation of epidermal growth factor receptor (EGF