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Heterophile igm, iga, and ige antibodies in infectious mononucleosis

✍ Scribed by G. Duverlie; M. Driencourt; C. Roussel; J. Orfila

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 376 KB
Volume: 28
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890280109

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✦ Synopsis

Fifty infectious mononucleosis (IM) and 150 noninfectious mononucleosis (non-IM) sera were tested by a hemadsorption immunocapture test (HIT) for the detection of heterophile antibodies of IgM, IgA, and IgE classes. The specificity of Paul-Bunnell (PB) antibodies was ascertained by a differential absorption test. IgM PB-antibodies were demonstrated in 100% of IM sera, IgA in 92%, and IgE in 88%. PB antibodies were present only in IM sera; but other heterophile antibodies of IgM (68%), IgA (6.7%), and IgE (9.3%) classes were demonstrated in non-IM sera. IgA and IgE heterophile antibodies were thus present, especially in IM sera. HIT was found to be more sensitive than Paul-Bunnell Davidsohn test (PBD test) and suitable for the diagnosis of infectious mononucleosis.

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