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Heteronuclear selective refocusing 2D NMR experiments for the spectral analysis of enantiomers in chiral oriented solvents

✍ Scribed by Jonathan Farjon; Jean-Pierre Baltaze; Philippe Lesot; Denis Merlet; Jacques Courtieu

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
122 KB
Volume
42
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

We report the use of carbon–proton heteronuclear selective refocusing 2D NMR experiments dedicated to the spectral analysis of enantiomers dissolved in weakly ordering chiral liquid crystalline solvents. The method permits the extraction of carbon–proton residual dipolar couplings for each enantiomer from a complex or unresolved proton‐coupled ^13^C spectral patterns. Illustrative examples are analysed and discussed. It is shown that an accurate determination of enantiomeric excess is possible. Copyright © 2004 John Wiley & Sons, Ltd.

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