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Simplification of the 1H NMR spectra of enantiomers dissolved in chiral liquid crystals, combining variable angle sample spinning and selective refocusing experiments

✍ Scribed by Laetitia Beguin; Jacques Courtieu; Latifa Ziani; Denis Merlet

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
217 KB
Volume
44
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

This work presents a technique to simplify overcrowded proton spectra in chiral liquid crystal solvents using rotation of the sample near the magic angle, VASS, combined with homonuclear selective refocusing 2D NMR experiments, SERF. This methodology provides a powerful tool to visualise enantiomers out of unresolved proton spectra. A modified SERF sequence is presented where the resulting 2D spectrum can be phased to increase the resolution. Accurate enantiomeric excesses are determined that are not possible to measure on static samples. Two examples are presented. Copyright © 2006 John Wiley & Sons, Ltd.

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